Epstein-Barr virus nuclear antigen 1 does not cause lymphoma in C57BL/6J mice.

نویسندگان

  • Myung-Soo Kang
  • Vishal Soni
  • Roderick Bronson
  • Elliott Kieff
چکیده

To test whether transgenic Epstein-Barr virus nuclear antigen 1 (EBNA1) expression in C57BL/6 mouse lymphocytes causes lymphoma, EBNA1 expressed in three FVB lineages at two or three times the level of latent infection was crossed up to six successive times into C57BL/6J mice. After five or six crosses, 14/36, (38%) EBNA1 transgenic mice, 11/31 (36%) littermate EBNA1-negative controls, and 9/25 (36%) inbred C57BL/6J mice housed in the same facility had lymphoma. These data indicate that EBNA1 does not significantly increase lymphoma prevalence in C57BL/6J mice.

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عنوان ژورنال:
  • Journal of virology

دوره 82 8  شماره 

صفحات  -

تاریخ انتشار 2008